| Departure: | Buffalo, NY | 
| Arrival: | St. Louis, MO | 
| Fastest route: | 15h 5min | 
| Distance: | 1223km | 
| Cheapest route: | $114.5 | 
| Transfers: | Between 1 and 2 | 
| Bus companies: | Greyhound, Barons Bus | 
One Passenger / One Trip
6:45am
Buffalo, NY
Transportation Center
2:00am
St. Louis, MO
St. Louis Greyhound Bus Station
20h 15min
++
$120.5
Multiple companies
6:45am
Buffalo, NY
Transportation Center
10:55am
Cleveland, OH
Greyhound Station
4h 10min
Greyhound
$23.5
0h 30min layover
11:25am
Cleveland, OH
Greyhound Station
2:20pm
Columbus, OH
Columbus Greyhound Bus Station
2h 55min
Barons Bus
$25
3h 45min layover
6:05pm
Columbus, OH
Columbus Greyhound Bus Station
2:00am
St. Louis, MO
St. Louis Greyhound Bus Station
8h 55min
Greyhound
$72
10:10am
Buffalo, NY
Transportation Center
2:00am
St. Louis, MO
St. Louis Greyhound Bus Station
16h 50min
++
$114.5
10:10am
Buffalo, NY
Transportation Center
2:00pm
Cleveland, OH
Greyhound Station
3h 50min
Greyhound
$26.5
0h 30min layover
2:30pm
Cleveland, OH
Greyhound Station
4:55pm
Columbus, OH
Columbus Greyhound Bus Station
2h 25min
Greyhound
$16
1h 10min layover
6:05pm
Columbus, OH
Columbus Greyhound Bus Station
2:00am
St. Louis, MO
St. Louis Greyhound Bus Station
8h 55min
Greyhound
$72
10:10am
Buffalo, NY
Transportation Center
2:00am
St. Louis, MO
St. Louis Greyhound Bus Station
16h 50min
+
$140
10:10am
Buffalo, NY
Transportation Center
10:00pm
Indianapolis, IN
Bus Station
11h 50min
Greyhound
$95
1h 5min layover
11:05pm
Indianapolis, IN
Bus Station
2:00am
St. Louis, MO
St. Louis Greyhound Bus Station
3h 55min
Greyhound
$45
4:05pm
Buffalo, NY
Transportation Center
6:10am
St. Louis, MO
St. Louis Greyhound Bus Station
15h 5min
+
$140
Multiple companies
4:05pm
Buffalo, NY
Transportation Center
2:25am
Indianapolis, IN
Bus Station
10h 20min
Barons Bus
$95
0h 50min layover
3:15am
Indianapolis, IN
Bus Station
6:10am
St. Louis, MO
St. Louis Greyhound Bus Station
3h 55min
Greyhound
$45
11:55pm
Buffalo, NY
Transportation Center
4:15pm
St. Louis, MO
St. Louis Greyhound Bus Station
17h 20min
++
$115.5
11:55pm
Buffalo, NY
Transportation Center
3:10am
Cleveland, OH
Greyhound Station
3h 15min
Greyhound
$28.5
1h 20min layover
4:30am
Cleveland, OH
Greyhound Station
6:55am
Columbus, OH
Columbus Greyhound Bus Station
2h 25min
Greyhound
$15
1h 0min layover
7:55am
Columbus, OH
Columbus Greyhound Bus Station
4:15pm
St. Louis, MO
St. Louis Greyhound Bus Station
9h 20min
Greyhound
$72
11:55pm
Buffalo, NY
Transportation Center
4:15pm
St. Louis, MO
St. Louis Greyhound Bus Station
17h 20min
+
$138
11:55pm
Buffalo, NY
Transportation Center
11:30am
Indianapolis, IN
Bus Station
11h 35min
Greyhound
$95
1h 10min layover
12:40pm
Indianapolis, IN
Bus Station
4:15pm
St. Louis, MO
St. Louis Greyhound Bus Station
4h 35min
Greyhound
$43
          The Buffalo - St. Louis route has approximately 6 frequencies and its minimum duration is around 15h 5min. It is important you book your ticket in advance to avoid running out, since $114.5 tickets tend to run out quickly. 
 The distance between Buffalo and St. Louis is around 1223 kilometers and the bus companies that can help you in your journey are: Greyhound, Barons Bus.
          
            
            Remember that the number of transfers to be made will be at least 1 so in some cases you should book the tickets separately.
          
        
Bus journey may vary depending on the state of the roads. The minimum duration is usually around 15h 5min to cover 1223 kilometers.
According to our data, the cheapest ticket costs $114.5 and leaves Transportation Center. If you decide to make this journey you will have to do 2 stops before reaching St. Louis Greyhound Bus Station.
Last bus leaves at 11:55pm from Transportation Center and arrives at 4:15pm at St. Louis Greyhound Bus Station. It will take 17h 20min, its price is $138 and the number of changes will be 1.
We do not have direct routes in our database. The minimum number of transfers will be 1 and the total duration of the trip will be approximately 16h 50min.